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As you get older, aches and pains become a more normal part of everyday life. Though most mean nothing, there are some symptoms that can indicate an underlying health problem. Below, we’ve listed out four symptoms that you should never ignore. If you or your loved one shows any of these signs, call the doctor and he or she can advise you of what to do next. It’s possible that you may need immediate help.

1. Weakness in the arms, legs or face.

Weakness or numbness in the arms, legs or face can be a sign of a stroke, especially if it’s only on one side. Other potential signs that you are having a stroke include dizziness, trouble balancing or trouble walking. If these symptoms are present with a bad headache, difficulty speaking or confusion, get help immediately. If a stroke is caught early enough, the damage can often be reversed.

2. Chest pain or pressure.

Any type of chest pain warrants a trip to the emergency room. It’s better to be safe than sorry. If the pain is accompanied by shortness of breath, sweating, pressure or nausea, you should be evaluated immediately. Chest pain or pressure can indicate a heart attack or heart disease, especially if it happens when you’re working out. You can first try taking deep breaths to see if the pain subsides, but if it doesn’t, head to the ER right away.

3. Tenderness and pain in the back of the lower leg.

Experiencing pain and tenderness in your lower leg may mean that you have a blood clot. This can happen if you’ve been sitting for a long time, such as in a car or plane. The leg will be large and tender, and you may notice some swelling. If it is a blood clot causing the discomfort, it will hurt to walk or stand up. Because blood clots can lead to heart attack or stroke, seek medical attention right away.

4. Blood in the urine.

If you have blood in the urine, plus pain in your side or back, it’s possible that you have kidney stones. Sometimes, kidney stones pass on their own. Other times, a doctor may have to remove the stones. It’s also possible that the blood you’re seeing is due to a bladder infection or kidney infection. Don’t wait to see a doctor, especially if you have a fever.

If you experience any of the above symptoms, get in touch with a medical professional immediately. In many cases, further damage can be prevented and possibly even reversed.